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Integrated proteomic and glycoproteomic characterization of human high-grade serous ovarian carcinoma

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Item Type:Article
Title:Integrated proteomic and glycoproteomic characterization of human high-grade serous ovarian carcinoma
Creators Name:Hu, Y. and Pan, J. and Shah, P. and Ao, M. and Thomas, S.N. and Liu, Y. and Chen, L. and Schnaubelt, M. and Clark, D.J. and Rodriguez, H. and Boja, E.S. and Hiltke, T. and Kinsinger, C.R. and Rodland, K.D. and Li, Q.K. and Qian, J. and Zhang, Z. and Chan, D.W. and Zhang, H.
Abstract:Many gene products exhibit great structural heterogeneity because of an array of modifications. These modifications are not directly encoded in the genomic template but often affect the functionality of proteins. Protein glycosylation plays a vital role in proper protein functions. However, the analysis of glycoproteins has been challenging compared with other protein modifications, such as phosphorylation. Here, we perform an integrated proteomic and glycoproteomic analysis of 83 prospectively collected high-grade serous ovarian carcinoma (HGSC) and 23 non-tumor tissues. Integration of the expression data from global proteomics and glycoproteomics reveals tumor-specific glycosylation, uncovers different glycosylation associated with three tumor clusters, and identifies glycosylation enzymes that were correlated with the altered glycosylation. In addition to providing a valuable resource, these results provide insights into the potential roles of glycosylation in the pathogenesis of HGSC, with the possibility of distinguishing pathological outcomes of ovarian tumors from non-tumors, as well as classifying tumor clusters.
Keywords:CPTAC, Glycosylation, Mass Spectrometry, Glycoproteomics, Tumor Clusters, High-Grade Serous Ovarian Carcinoma, HGSC, Proteomics
Source:Cell Reports
ISSN:2211-1247
Publisher:Cell Press / Elsevier
Volume:33
Number:3
Page Range:108276
Date:20 October 2020
Additional Information:Philipp Mertins is a member of the National Cancer Institute Clinical Proteomic Tumor Analysis Consortium.
Official Publication:https://doi.org/10.1016/j.celrep.2020.108276
PubMed:View item in PubMed

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