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Long-lived tumor-associated macrophages in glioma

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Item Type:Article
Title:Long-lived tumor-associated macrophages in glioma
Creators Name:Georgieva, P.B. and Mathivet, T. and Alt, S. and Giese, W. and Riva, M. and Balcer, M. and Gerhardt, H.
Abstract:BACKGROUND: The tumor microenvironment (TME) plays a major tumor-supportive role in glioma. In particular, tumor-associated macrophages (TAMs), which can make up to one third of the tumor mass, actively support tumor growth, invasion and angiogenesis. Predominantly alternatively activated (M2-polarized) TAMs are found in late stage glioma in both human and mouse tumors, as well as in relapse samples from patients. However, whether tumor-educated M2 TAMs can actively contribute to the emergence and growth of relapse is currently debated. METHODS: To investigate whether tumor-educated stromal cells remaining in the brain after surgical removal of the primary tumor can be long-lived and retain their tumor-supporting function, we developed a transplantation mouse model and performed lineage-tracing. RESULTS: We discovered that macrophages can survive transplantation and stay present in the tumor much longer than previously suggested, while sustaining an M2 polarized pro-tumorigenic phenotype. Transplanted tumors showed a more aggressive growth and faster polarization of the TAMs toward an M2 phenotype compared to primary tumors, a process dependent on the presence of few co-transplanted macrophages. CONCLUSIONS: Overall, we propose a new way for tumor-educated TAMs to contribute to glioma aggressiveness by long survival and stable pro-tumorigenic features. These properties could have a relapse-supporting effect.
Keywords:Glioma, Tumor-Associated Macrophages, Tumor Transplantation, Long-Lived Macrophages, Tumor Microenvironment, Animals, Mice
Source:Neuro-Oncology Advances
Publisher:Oxford University Press
Page Range:vdaa127
Date:9 November 2020
Additional Information:Copyright © The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Official Publication:https://doi.org/10.1093/noajnl/vdaa127
PubMed:View item in PubMed

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