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Cells of the adult human heart

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Item Type:Article
Title:Cells of the adult human heart
Creators Name:Litviňuková, M. and Talavera-López, C. and Maatz, H. and Reichart, D. and Worth, C.L. and Lindberg, E.L. and Kanda, M. and Polanski, K. and Heinig, M. and Lee, M.l and Nadelmann, E.R. and Roberts, K. and Tuck, L. and Fasouli, E.S. and DeLaughter, D.M. and McDonough, B. and Wakimoto, H. and Gorham, J.M. and Samari, S. and Mahbubani, K.T. and Saeb-Parsy, K. and Patone, G. and Boyle, J.J. and Zhang, H. and Zhang, H. and Viveiros, A. and Oudit, G.Y. and Bayraktar, O. and Seidman, J.G. and Seidman, C.E. and Noseda, M. and Hubner, N. and Teichmann, S.A.
Abstract:Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require deeper understanding of the healthy heart's molecular processes. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavor. Here, using state-of-the-art analyses of large-scale single-cell and nuclei transcriptomes, we characterise six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes, and fibroblasts, revealing distinct atrial and ventricular subsets with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment we identify cardiac resident macrophages with inflammatory and protective transcriptional signatures. Further, inference of cell-cell interactions highlight different macrophage-fibroblast-cardiomyocyte networks between atria and ventricles that are distinct from skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a healthy reference for future studies.
Keywords:Adipocytes, Angiotensin-Converting Enzyme 2, Cardiac Myocytes, Coronavirus Receptors, Epithelial Cells, Epithelium, Fibroblasts, Gene Expression Profiling, Genome-Wide Association Study, Heart Atria, Heart Ventricles, Homeostasis, Macrophages, Myocardium, Neurons, Pericytes, SARS-CoV-2, Single-Cell Analysis, Skeletal Muscle, Stromal Cells, Transcriptome
Source:Nature
ISSN:0028-0836
Publisher:Nature Publishing Group
Volume:588
Number:7838
Page Range:466-472
Date:17 December 2020
Official Publication:https://doi.org/10.1038/s41586-020-2797-4
PubMed:View item in PubMed

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