A palladium-catalyzed domino reaction to access 3-amino-2H-indazoles from hydrazines and 2-halobenzonitriles

Item Type:	Article
Title:	A palladium-catalyzed domino reaction to access 3-amino-2H-indazoles from hydrazines and 2-halobenzonitriles
Creators Name:	Alsalim, R. and Lindemann, P. and López-Alberca, M.P. and Miksche, S. and Czechtizky, W. and Halland, N. and Nazaré, M.
Abstract:	The development of a novel selective synthesis of 3-amino-2H-indazoles from readily available 2-halobenzonitriles is presented. The reaction proceeds through a domino reaction sequence, consisting of a regioselective palladium-catalyzed coupling of monosubstituted hydrazines with 2-halobenzonitriles, followed by an intramolecular hydroamination through a 5-exo-dig cyclization and subsequent isomerization to directly afford a wide variety of substituted 2H-indazole analogues in good to excellent yields.
Source:	Organic Letters
ISSN:	1523-7060
Publisher:	American Chemical Society
Volume:	22
Number:	18
Page Range:	7393-7396
Date:	18 September 2020
Official Publication:	https://doi.org/10.1021/acs.orglett.0c02766
PubMed:	View item in PubMed

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