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Vascular heterogeneity and specialization in development and disease

Item Type:Review
Title:Vascular heterogeneity and specialization in development and disease
Creators Name:Potente, M. and Mäkinen, T.
Abstract:Blood and lymphatic vessels pervade almost all body tissues and have numerous essential roles in physiology and disease. The inner lining of these networks is formed by a single layer of endothelial cells, which is specialized according to the needs of the tissue that it supplies. Whereas the general mechanisms of blood and lymphatic vessel development are being defined with increasing molecular precision, studies of the processes of endothelial specialization remain mostly descriptive. Recent insights from genetic animal models illuminate how endothelial cells interact with each other and with their tissue environment, providing paradigms for vessel type- and organ-specific endothelial differentiation. Delineating these governing principles will be crucial for understanding how tissues develop and maintain, and how their function becomes abnormal in disease.
Keywords:Blood Vessels, Cell Differentiation, Endothelial Cells, Lymphatic Vessels, Animals
Source:Nature Reviews Molecular Cell Biology
Publisher:Nature Publishing Group
Page Range:477-494
Date:August 2017
Official Publication:https://doi.org/10.1038/nrm.2017.36
PubMed:View item in PubMed

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