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Visual system damage and network maladaptation are associated with cognitive performance in neuromyelitis optica spectrum disorders

Item Type:Article
Title:Visual system damage and network maladaptation are associated with cognitive performance in neuromyelitis optica spectrum disorders
Creators Name:Chavarro, V.S. and Bellmann-Strobl, J. and Zimmermann, H.G. and Scheel, M. and Chien, C. and Oertel, F.C. and Weygandt, M. and Ruprecht, K. and Paul, F. and Finke, C. and Brandt, A.U.
Abstract:BACKGROUND: Neuromyelitis Optica Spectrum Disorders (NMOSD) is an autoimmune disease leading to disability from optic neuritis, myelitis and more rarely brain stem attacks and encephalitis. Patients with NMOSD also exhibit cognitive deficits, the cause of which remains unclear. Recent evidence highlights sensory-cognitive parallel processing converging on the primary visual cortex. The objective of this study was to investigate the effect of the primary visual network disruption from damage caused by optic neuritis on cognition in NMOSD. METHODS: Twenty-nine aquaporin-4 antibody seropositive patients with NMOSD and 22 healthy controls (HC) completed the brief repeatable battery of neuropsychological tests (BRB-N) and underwent 3 Tesla MRI. Primary visual network functional connectivity (FC) at resting state was analyzed and correlated with performance on BRB-N. These correlations were compared between the groups. RESULTS: Patients performed significantly worse than HC on the BRB-N Index score (t = 2.366, p = 0.02). Among HC, visual network FC decreased significantly as cognitive performance on the BRB-N Index score increased (rho(17)=-0.507, p = 0.02). Among patients, this association was absent (rho(23)=0.197, p = 0.18), and the difference in correlation direction and strength to HC was significant (z=-2.175, p = 0.01). Visual network FC was able to explain 19% of the variance in cognitive performance in HC, but none in patients. CONCLUSIONS: A physiological association of the primary visual network FC and cognitive performance appears absent in patients with NMOSD, suggesting a partial explanation for cognitive deficits. Our findings extend neuroscientific concepts on sensory-cognitive parallel processing neural networks to a clearly defined pathological state, and may be relevant for other diseases with visual system damage.
Keywords:Neuromyelitis Optica, Visual Function, Cognition, Visual Cortex, Resting State Functional Magnetic Resonance Imaging, Neuromyelitis Optica Spectrum Disorder, Functional Connectivity, Neuropsychology and Cognition, Visual Function
Source:Multiple Sclerosis and Related Disorders
Page Range:102406
Date:October 2020
Official Publication:https://doi.org/10.1016/j.msard.2020.102406
PubMed:View item in PubMed

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