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Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils

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Item Type:Article
Title:Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils
Creators Name:Cerofolini, L. and Ravera, E. and Bologna, S. and Wiglenda, T. and Böddrich, A. and Purfürst, B. and Benilova, I. and Korsak, M. and Gallo, G. and Rizzo, D. and Gonnelli, L. and Fragai, M. and De Strooper, B. and Wanker, E.E. and Luchinat, C.
Abstract:Recent structural studies show distinct morphologies for the fibrilsof Ab(1-42) and Ab(1-40), which are believed not to co-fibrillize.We describe here a novel, structurally-uniform 1 : 1 mixed fibrillarspecies, which differs from bothpure fibrils. It forms preferen-tially even when Ab(1-42) : Ab(1-40) peptides are mixed in a non-stoichiometric ratio.
Source:Chemical Communications
ISSN:1359-7345
Publisher:Royal Society of Chemistry
Volume:56
Number:62
Page Range:8830-8833
Date:11 August 2020
Official Publication:https://doi.org/10.1039/d0cc02463e
PubMed:View item in PubMed

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