Identifying progression in multiple sclerosis: new perspectives

Item Type:	Review
Title:	Identifying progression in multiple sclerosis: new perspectives
Creators Name:	Filippi, M. and Preziosa, P. and Langdon, D. and Lassmann, H. and Paul, F. and Rovira, À. and Schoonheim, M.M. and Solari, A. and Stankoff, B. and Rocca, M.A.
Abstract:	The identification of progression in multiple sclerosis is typically retrospective. Given the profound burden of progressive multiple sclerosis, and the recent development of effective treatments for these patients, there is a need to establish measures capable of identifying progressive multiple sclerosis early in the disease course. Starting from recent pathological findings, this review assesses the state-of-the-art of potential measures able to predict progressive multiple sclerosis. Future promising biomarkers, that might shed light on mechanisms of progression are also discussed. Finally, expansion of the concept of progressive multiple sclerosis, by including an assessment of cognition, patient-reported outcomes and comorbidities, is considered.
Keywords:	Multiple Sclerosis, Progression, Neurodegeneration, Magnetic Resonance Imaging, Biomarkers
Source:	Annals of Neurology
ISSN:	0364-5134
Publisher:	Wiley
Volume:	88
Number:	3
Page Range:	438-452
Date:	September 2020
Official Publication:	https://doi.org/10.1002/ana.25808
PubMed:	View item in PubMed

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