Helmholtz Gemeinschaft


Small ones to fight a big problem-intervention of cancer metastasis by small molecules

PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader

Item Type:Review
Title:Small ones to fight a big problem-intervention of cancer metastasis by small molecules
Creators Name:Kobelt, D. and Dahlmann, M. and Dumbani, M. and Güllü, N. and Kortüm, B. and Vílchez, M.E.A. and Stein, U. and Walther, W.
Abstract:Metastasis represents the most lethal attribute of cancer and critically limits successful therapies in many tumor entities. The clinical need is defined by the fact that all cancer patients, who have or who will develop distant metastasis, will experience shorter survival. Thus, the ultimate goal in cancer therapy is the restriction of solid cancer metastasis by novel molecularly targeted small molecule based therapies. Biomarkers identifying cancer patients at high risk for metastasis and simultaneously acting as key drivers for metastasis are extremely desired. Clinical interventions targeting these key molecules will result in high efficiency in metastasis intervention. In result of this, personalized tailored interventions for restriction and prevention of cancer progression and metastasis will improve patient survival. This review defines crucial biological steps of the metastatic cascade, such as cell dissemination, migration and invasion as well as the action of metastasis suppressors. Targeting these biological steps with tailored therapeutic strategies of intervention or even prevention of metastasis using a wide range of small molecules will be discussed.
Keywords:Cancer Metastasis, Solid Cancer, Intervention, Small Molecules, Inhibitors
Page Range:1454
Date:3 June 2020
Official Publication:https://doi.org/10.3390/cancers12061454
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library