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Serotonin suppresses slow oscillations by activating somatostatin interneurons via the 5-HT(2A) receptor

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Title:Serotonin suppresses slow oscillations by activating somatostatin interneurons via the 5-HT(2A) receptor
Creators Name:de Filippo, R. and Rost, B. and Stumpf, A. and Cooper, C. and Tukker, J.J. and Harms, C. and Beed, P. and Schmitz, D.
Abstract:Serotonin (5-HT) affects multiple physiological processes in the brain and is involved in a number of psychiatric disorders. 5-HT axons reach all cortical areas; however, the precise mechanism by which 5-HT modulates cortical network activity is not yet fully understood. We investigated the effects of 5-HT on slow oscillations (SO), a synchronized cortical network activity universally present across species. SO are observed during slow-wave sleep and anesthesia and are considered the default cortical activity pattern. Combining opto- and pharmacogenetic manipulations with electrophysiological recordings, we discovered that 5-HT inhibits SO within the entorhinal cortex (EC) by activating somatostatin-expressing (Som) interneurons via the 5-HT(2A) receptor (5-HT(2A)R). This receptor is involved in the etiology of different psychiatric disorders and mediates the psychological effects of many psychoactive serotonergic drugs, suggesting that 5-HT targeting of Som interneurons may play an important role in these processes.
Keywords:Serotonin, 5-HT(2A), Somatostatin Interneurons, Slow Oscillations, MDMA, Entorhinal Cortex, Animals, Mice
Source:bioRxiv
Publisher:Cold Spring Harbor Laboratory Press
Article Number:2020.05.26.113373
Date:26 May 2020
Official Publication:https://doi.org/10.1101/2020.05.26.113373

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