![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Preprint)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
7MB |
| Item Type: | Preprint |
|---|---|
| Title: | Serotonin suppresses slow oscillations by activating somatostatin interneurons via the 5-HT(2A) receptor |
| Creators Name: | de Filippo, R., Rost, B., Stumpf, A., Cooper, C., Tukker, J.J., Harms, C., Beed, P. and Schmitz, D. |
| Abstract: | Serotonin (5-HT) affects multiple physiological processes in the brain and is involved in a number of psychiatric disorders. 5-HT axons reach all cortical areas; however, the precise mechanism by which 5-HT modulates cortical network activity is not yet fully understood. We investigated the effects of 5-HT on slow oscillations (SO), a synchronized cortical network activity universally present across species. SO are observed during slow-wave sleep and anesthesia and are considered the default cortical activity pattern. Combining opto- and pharmacogenetic manipulations with electrophysiological recordings, we discovered that 5-HT inhibits SO within the entorhinal cortex (EC) by activating somatostatin-expressing (Som) interneurons via the 5-HT(2A) receptor (5-HT(2A)R). This receptor is involved in the etiology of different psychiatric disorders and mediates the psychological effects of many psychoactive serotonergic drugs, suggesting that 5-HT targeting of Som interneurons may play an important role in these processes. |
| Keywords: | Serotonin, 5-HT(2A), Somatostatin Interneurons, Slow Oscillations, MDMA, Entorhinal Cortex, Animals, Mice |
| Source: | bioRxiv |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Article Number: | 2020.05.26.113373 |
| Date: | 26 May 2020 |
| Official Publication: | https://doi.org/10.1101/2020.05.26.113373 |
Repository Staff Only: item control page
