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In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma

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Item Type:Article
Title:In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma
Creators Name:Philipp-Abbrederis, K. and Herrmann, K. and Knop, S. and Schottelius, M. and Eiber, M. and Lückerath, K. and Pietschmann, E. and Habringer, S. and Gerngroß, C. and Franke, K. and Rudelius, M. and Schirbel, A. and Lapa, C. and Schwamborn, K. and Steidle, S. and Hartmann, E. and Rosenwald, A. and Kropf, S. and Beer, A.J. and Peschel, C. and Einsele, H. and Buck, An.K. and Schwaiger, M. and Götze, K. and Wester, H.J. and Keller, U.
Abstract:CXCR4 is a G-protein-coupled receptor that mediates recruitment of blood cells toward its ligand SDF-1. In cancer, high CXCR4 expression is frequently associated with tumor dissemination and poor prognosis. We evaluated the novel CXCR4 probe [(68)Ga]Pentixafor for in vivo mapping of CXCR4 expression density in mice xenografted with human CXCR4-positive MM cell lines and patients with advanced MM by means of positron emission tomography (PET). [(68)Ga]Pentixafor PET provided images with excellent specificity and contrast. In 10 of 14 patients with advanced MM [(68)Ga]Pentixafor PET/CT scans revealed MM manifestations, whereas only nine of 14 standard [(18)F]fluorodeoxyglucose PET/CT scans were rated visually positive. Assessment of blood counts and standard CD34(+) flow cytometry did not reveal significant blood count changes associated with tracer application. Based on these highly encouraging data on clinical PET imaging of CXCR4 expression in a cohort of MM patients, we conclude that [(68)Ga]Pentixafor PET opens a broad field for clinical investigations on CXCR4 expression and for CXCR4-directed therapeutic approaches in MM and other diseases.
Keywords:Chemokine Receptor, CXCR4, In Vivo Imaging, Multiple Myeloma, Positron Emission Tomography, Animals, Mice
Source:EMBO Molecular Medicine
ISSN:1757-4676
Publisher:Wiley-Blackwell
Volume:7
Number:4
Page Range:477-487
Date:1 April 2015
Official Publication:https://doi.org/10.15252/emmm.201404698
PubMed:View item in PubMed

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