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| Item Type: | Article |
|---|---|
| Title: | In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma |
| Creators Name: | Philipp-Abbrederis, K., Herrmann, K., Knop, S., Schottelius, M., Eiber, M., Lückerath, K., Pietschmann, E., Habringer, S., Gerngroß, C., Franke, K., Rudelius, M., Schirbel, A., Lapa, C., Schwamborn, K., Steidle, S., Hartmann, E., Rosenwald, A., Kropf, S., Beer, A.J., Peschel, C., Einsele, H., Buck, An.K., Schwaiger, M., Götze, K., Wester, H.J. and Keller, U. |
| Abstract: | CXCR4 is a G-protein-coupled receptor that mediates recruitment of blood cells toward its ligand SDF-1. In cancer, high CXCR4 expression is frequently associated with tumor dissemination and poor prognosis. We evaluated the novel CXCR4 probe [(68)Ga]Pentixafor for in vivo mapping of CXCR4 expression density in mice xenografted with human CXCR4-positive MM cell lines and patients with advanced MM by means of positron emission tomography (PET). [(68)Ga]Pentixafor PET provided images with excellent specificity and contrast. In 10 of 14 patients with advanced MM [(68)Ga]Pentixafor PET/CT scans revealed MM manifestations, whereas only nine of 14 standard [(18)F]fluorodeoxyglucose PET/CT scans were rated visually positive. Assessment of blood counts and standard CD34(+) flow cytometry did not reveal significant blood count changes associated with tracer application. Based on these highly encouraging data on clinical PET imaging of CXCR4 expression in a cohort of MM patients, we conclude that [(68)Ga]Pentixafor PET opens a broad field for clinical investigations on CXCR4 expression and for CXCR4-directed therapeutic approaches in MM and other diseases. |
| Keywords: | Chemokine Receptor, CXCR4, In Vivo Imaging, Multiple Myeloma, Positron Emission Tomography, Animals, Mice |
| Source: | EMBO Molecular Medicine |
| ISSN: | 1757-4676 |
| Publisher: | EMBO Press / Wiley |
| Volume: | 7 |
| Number: | 4 |
| Page Range: | 477-487 |
| Date: | 1 April 2015 |
| Official Publication: | https://doi.org/10.15252/emmm.201404698 |
| PubMed: | View item in PubMed |
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