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NF-κB signaling in tanycytes mediates inflammation-induced anorexia

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Item Type:Article
Title:NF-κB signaling in tanycytes mediates inflammation-induced anorexia
Creators Name:Böttcher, M. and Müller-Fielitz, H. and Sundaram, S.M. and Gallet, S. and Neve, V. and Shionoya, K. and Zager, A. and Quan, N. and Liu, X. and Schmidt-Ullrich, R. and Haenold, R. and Wenzel, J. and Blomqvist, A. and Engblom, D. and Prevot, V. and Schwaninger, M.
Abstract:OBJECTIVES: Infections, cancer and systemic inflammation elicit anorexia. Despite the medical significance of this phenomenon, the question of how peripheral inflammatory mediators affect the central regulation of food intake is incompletely understood. Therefore, we have investigated the sickness behavior induced by the prototypical inflammatory mediator IL-1β. METHODS: IL-1β was injected intravenously. To interfere with IL-1β signaling we deleted the essential modulator of NF-κB signaling (Nemo) in astrocytes and tanycytes. RESULTS: Systemic IL-1β increased the activity of the transcription factor NF-κB in tanycytes of the mediobasal hypothalamus (MBH). By activating NF-κB signaling, IL-1β induced the expression of cyclooxygenase-2 (Cox-2) and stimulated the release of the anorexigenic prostaglandin E(2) (PGE(2)) from tanycytes. When we deleted Nemo in astrocytes and tanycytes, the IL-1β-induced anorexia was alleviated whereas the fever and lethargy response were unchanged. Similar results were obtained after selective deletion of Nemo exclusively in tanycytes. CONCLUSIONS: Tanycytes form the brain barrier that mediates the anorexic effect of systemic inflammation in the hypothalamus.
Keywords:Tanycytes, Inflammation-Induced Anorexia, IL-1β, NEMO, Animals, Mice, Rats
Source:Molecular Metabolism
Page Range:101022
Date:September 2020
Official Publication:https://doi.org/10.1016/j.molmet.2020.101022
PubMed:View item in PubMed

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