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Solving the time- and frequency-multiplexed problem of constrained radiofrequency induced hyperthermia

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Item Type:Article
Title:Solving the time- and frequency-multiplexed problem of constrained radiofrequency induced hyperthermia
Creators Name:Kuehne, A. and Oberacker, E. and Waiczies, H. and Niendorf, T.
Abstract:Targeted radiofrequency (RF) heating induced hyperthermia has a wide range of applications, ranging from adjunct anti-cancer treatment to localized release of drugs. Focal RF heating is usually approached using time-consuming nonconvex optimization procedures or approximations, which significantly hampers its application. To address this limitation, this work presents an algorithm that recasts the problem as a semidefinite program and quickly solves it to global optimality, even for very large (human voxel) models. The target region and a desired RF power deposition pattern as well as constraints can be freely defined on a voxel level, and the optimum application RF frequencies and time-multiplexed RF excitations are automatically determined. 2D and 3D example applications conducted for test objects containing pure water (r(target) = 19 mm, frequency range: 500–2000 MHz) and for human brain models including brain tumors of various size (r(1) = 20 mm, r(2) = 30 mm, frequency range 100–1000 MHz) and locations (center, off-center, disjoint) demonstrate the applicability and capabilities of the proposed approach. Due to its high performance, the algorithm can solve typical clinical problems in a few seconds, making the presented approach ideally suited for interactive hyperthermia treatment planning, thermal dose and safety management, and the design, rapid evaluation, and comparison of RF applicator configurations.
Keywords:RF Hyperthermia, Thermal Intervention, Field Shaping, Field Focusing, RF Applicator, Hyperthermia Treatment Planning, Thermal Magnetic Resonance, Semidefinite Programming
Page Range:1072
Date:May 2020
Official Publication:https://doi.org/10.3390/cancers12051072
PubMed:View item in PubMed

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