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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Item Type:Article
Title:SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
Creators Name:Sungnak, W. and Huang, N. and Bécavin, C. and Berg, M. and Queen, R. and Litvinukova, M. and Talavera-López, C. and Maatz, H. and Reichart, D. and Sampaziotis, F. and Worlock, K.B. and Yoshida, M. and Barnes, J.L.
Abstract:We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
Source:Nature Medicine
ISSN:1078-8956
Publisher:Nature Publishing Group
Volume:26
Number:5
Page Range:681-687
Date:May 2020
Additional Information:Norbert Hübner is a member of the HCA Lung Biological Network.
Official Publication:https://doi.org/10.1038/s41591-020-0868-6
PubMed:View item in PubMed

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