Item Type: | Article |
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Title: | SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes |
Creators Name: | Sungnak, W. and Huang, N. and Bécavin, C. and Berg, M. and Queen, R. and Litvinukova, M. and Talavera-López, C. and Maatz, H. and Reichart, D. and Sampaziotis, F. and Worlock, K.B. and Yoshida, M. and Barnes, J.L. |
Abstract: | We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org. |
Source: | Nature Medicine |
ISSN: | 1078-8956 |
Publisher: | Nature Publishing Group |
Volume: | 26 |
Number: | 5 |
Page Range: | 681-687 |
Date: | May 2020 |
Additional Information: | Norbert Hübner is a member of the HCA Lung Biological Network. Copyright © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. |
Official Publication: | https://doi.org/10.1038/s41591-020-0868-6 |
External Fulltext: | View full text on PubMed Central |
PubMed: | View item in PubMed |
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