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| Item Type: | Article |
|---|---|
| Title: | Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway |
| Creators Name: | Nitzan, N. and McKenzie, S. and Beed, P. and English, D.F. and Oldani, S. and Tukker, J.J. and Buzsáki, G. and Schmitz, D. |
| Abstract: | Bouts of high frequency activity known as sharp wave ripples (SPW-Rs) facilitate communication between the hippocampus and neocortex. However, the paths and mechanisms by which SPW-Rs broadcast their content are not well understood. Due to its anatomical positioning, the granular retrosplenial cortex (gRSC) may be a bridge for this hippocampo-cortical dialogue. Using silicon probe recordings in awake, head-fixed mice, we show the existence of SPW-R analogues in gRSC and demonstrate their coupling to hippocampal SPW-Rs. gRSC neurons reliably distinguished different subclasses of hippocampal SPW-Rs according to ensemble activity patterns in CA1. We demonstrate that this coupling is brain state-dependent, and delineate a topographically-organized anatomical pathway via VGlut2-expressing, bursty neurons in the subiculum. Optogenetic stimulation or inhibition of bursty subicular cells induced or reduced responses in superficial gRSC, respectively. These results identify a specific path and underlying mechanisms by which the hippocampus can convey neuronal content to the neocortex during SPW-Rs. |
| Keywords: | Brain Waves, Hippocampal CA1 Region, Hippocampus, Neocortex, Neural Pathways, Neurons, Synaptic Transmission, Transgenic Mice, Vesicular Glutamate Transport Protein 2, Wakefulness, Animals, Mice |
| Source: | Nature Communications |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Volume: | 11 |
| Number: | 1 |
| Page Range: | 1947 |
| Date: | 23 April 2020 |
| Additional Information: | Erratum in: Nat Commun 11(1): 3472. |
| Official Publication: | https://doi.org/10.1038/s41467-020-15787-8 |
| PubMed: | View item in PubMed |
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