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Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway

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Item Type:Article
Title:Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway
Creators Name:Nitzan, N. and McKenzie, S. and Beed, P. and English, D.F. and Oldani, S. and Tukker, J.J. and Buzsáki, G. and Schmitz, D.
Abstract:Bouts of high frequency activity known as sharp wave ripples (SPW-Rs) facilitate communication between the hippocampus and neocortex. However, the paths and mechanisms by which SPW-Rs broadcast their content are not well understood. Due to its anatomical positioning, the granular retrosplenial cortex (gRSC) may be a bridge for this hippocampo-cortical dialogue. Using silicon probe recordings in awake, head-fixed mice, we show the existence of SPW-R analogues in gRSC and demonstrate their coupling to hippocampal SPW-Rs. gRSC neurons reliably distinguished different subclasses of hippocampal SPW-Rs according to ensemble activity patterns in CA1. We demonstrate that this coupling is brain state-dependent, and delineate a topographically-organized anatomical pathway via VGlut2-expressing, bursty neurons in the subiculum. Optogenetic stimulation or inhibition of bursty subicular cells induced or reduced responses in superficial gRSC, respectively. These results identify a specific path and underlying mechanisms by which the hippocampus can convey neuronal content to the neocortex during SPW-Rs.
Keywords:Brain Waves, Hippocampal CA1 Region, Hippocampus, Neocortex, Neural Pathways, Neurons, Synaptic Transmission, Transgenic Mice, Vesicular Glutamate Transport Protein 2, Wakefulness, Animals, Mice
Source:Nature Communications
Publisher:Nature Publishing Group
Page Range:1947
Date:23 April 2020
Additional Information:Erratum in: Nat Commun 11(1): 3472.
Official Publication:https://doi.org/10.1038/s41467-020-15787-8
PubMed:View item in PubMed

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