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Evolution of new proteins from translated sORFs in long non-coding RNAs

Item Type:Review
Title:Evolution of new proteins from translated sORFs in long non-coding RNAs
Creators Name:Ruiz-Orera, J. and Villanueva-Cañas, J.L. and Albà, M.M.
Abstract:High throughput RNA sequencing techniques have revealed that a large fraction of the genome is transcribed into long non-coding RNAs (lncRNAs). Unlike canonical protein-coding genes, lncRNAs do not contain long open reading frames (ORFs) and tend to be poorly conserved across species. However, many of them contain small ORFs (sORFs) that exhibit translation signatures according to ribosome profiling or proteomics data. These sORFs are a source of putative novel proteins; some of them may confer a selective advantage and be maintained over time, a process known as de novo gene birth. Here we review the mechanisms by which randomly occurring sORFs in lncRNAs can become new functional proteins.
Keywords:Long Non-Coding RNA, Transcriptomics, Ribosome Profiling, sORF, de novo Gene, Animals
Source:Experimental Cell Research
Page Range:111940
Date:1 June 2020
Official Publication:https://doi.org/10.1016/j.yexcr.2020.111940
PubMed:View item in PubMed

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