Helmholtz Gemeinschaft


Lungenfunktion in der NAKO Gesundheitsstudie: Methoden und erste Ergebnisse [Lung function in the German National Cohort: methods and initial results]

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Item Type:Article
Title:Lungenfunktion in der NAKO Gesundheitsstudie: Methoden und erste Ergebnisse [Lung function in the German National Cohort: methods and initial results]
Creators Name:Karrasch, S. and Peters, A. and Meisinger, C. and Ferland, M. and Jaeschke, L. and Pischon, T. and Fricke, J. and Keil, T. and Gastell, S. and Schulze, M. and Brandes, M. and Günther, K. and Kuß, O. and Schikowski, T. and Emmel, C. and Jöckel, K.H. and Michels, K.B. and Franzke, C.W. and Langer, S. and Mikolajczyk, R. and Jagodzinski, A. and Becher, H. and Castell, S. and Kemmling, Y. and Waniek, S. and Lieb, W. and Wirkner, K. and Loeffler, M. and Greiser, K.H. and Kaaks, R. and Legath, N. and Berger, K. and Schipf, S. and Hoffmann, W. and Sedlmeier, A. and Leitzmann, M. and Brenner, H. and Holleczek, B. and Schulz, H.
Abstract:BACKGROUND: A nationwide assessment of the respiratory status on the basis of standardized lung function measurements has so far not been available in Germany. The present work describes the lung function tests in the German National Cohort (GNC) and presents initial results based on the GNC Midterm Baseline Dataset. MATERIAL AND METHODS: The assessment of lung function in the GNC comprised spirometry (level 1) and the determination of exhaled nitric oxide (FeNO, level 2). Our quality assurance concept included regular training of lung function test procedures at various GNC sites, interim evaluations of test quality, as well as regular calibration/measurement checks of test equipment. For spirometry, we established a stepwise procedure for offline quality control based on raw flow volume curves. RESULTS: In the present dataset (n = 101,734), spirometry was available for 86,893 study participants and FeNO was available for 15,228 participants. The average (±SD) FEV(1) Z score (according to GLI 2012) was -0.321 ± 1.047, the FVC Z score was -0.153 ± 0.941, and the FEV(1)/FVC Z score was -0.337 ± 0.901. The difference in FEV(1)/FVC between current smokers and never-smokers increased with age. The average FeNO was 14.2 ÷ 2.0 ppb. Current smoking reduced FeNO levels by 43%, whereas respiratory allergy increased FeNO levels by 16% in nonsmokers. DISCUSSION: The results of spirometry and the FeNO measurements are in the expected range with regard to their distributions and correlates. The GNC provides a valuable basis for future investigations of respiratory health and its determinants as well as research into the prevention of respiratory diseases in Germany.
Keywords:Spirometry, FeNO, German National Cohort, Asthma, COPD
Source:Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Page Range:322-331
Date:March 2020
Official Publication:https://doi.org/10.1007/s00103-020-03102-1
PubMed:View item in PubMed

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