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New aspects in cardiac L-type Ca(2+) channel regulation

Item Type:Review
Title:New aspects in cardiac L-type Ca(2+) channel regulation
Creators Name:Pallien, T. and Klussmann, E.
Abstract:Cardiac excitation-contraction coupling is initiated with the influx of Ca2+ ions across the plasma membrane through voltage-gated L-type calcium channels. This process is tightly regulated by modulation of the channel open probability and channel localization. Protein kinase A (PKA) is found in close association with the channel and is one of the main regulators of its function. Whether this kinase is modulating the channel open probability by phosphorylation of key residues or via alternative mechanisms is unclear. This review summarizes recent findings regarding the PKA-mediated channel modulation and will highlight recently discovered regulatory mechanisms that are independent of PKA activity and involve protein-protein interactions and channel localization.
Keywords:AKAP, Ca2+, Ca2+ Channel, Compartmentalization, LTCC, PKA, Animals
Source:Biochemical Society Transactions
Publisher:Portland Press
Page Range:39-49
Date:February 2020
Official Publication:https://doi.org/10.1042/BST20190229
PubMed:View item in PubMed

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