Schwere Azidose: Differenzialdiagnostik und Therapie [Severe acidosis: differential diagnostics and treatment]

Item Type:	Review
Title:	Schwere Azidose: Differenzialdiagnostik und Therapie [Severe acidosis: differential diagnostics and treatment]
Creators Name:	Lehner, L.J. and Oppert, M. and Kettritz, R.
Abstract:	The extracellular H(+) ion concentration in the human body is adjusted within close limits to 40 ± 0.3 nmol/l in blood to ensure maintenance of normal cellular and extracellular homeostasis. The carbonic acid-bicarbonate buffer system is the major regulator of acid-base homeostasis and is readily accessible for the clinician through determination of pH, pCO(2) and HCO3(–). Acidosis is primarily a respiratory or metabolic disorder causing acidemia (H(+) >43 nmol/l or pH <7.37). Severe acidosis (H(+) >60 nmol/l or pH <7.2) needs to be diagnosed rapidly and treated according to the underlying condition. A systematic approach with simple bedside diagnostic tools helps to characterize the underlying acid-base disorder, to identify the etiology and to initiate the appropriate causal treatment.
Keywords:	Acid-Base Equilibrium, Anion Gap, Buffer System, Diagnosis, Therapeutics
Source:	Nephrologe
ISSN:	1862-040X
Publisher:	Springer
Volume:	14
Number:	6
Page Range:	431-437
Date:	November 2019
Official Publication:	https://doi.org/10.1007/s11560-019-00374-w

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