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| Item Type: | Article |
|---|---|
| Title: | A multi-vendor, multi-center study on reproducibility and comparability of fast strain-encoded cardiovascular magnetic resonance imaging |
| Creators Name: | Erley, J. and Zieschang, V. and Lapinskas, T. and Demir, A. and Wiesemann, S. and Haass, M. and Osman, N.F. and Simonetti, O.P. and Liu, Y. and Patel, A.R. and Mor-Avi, V. and Unal, O. and Johnson, K.M. and Pieske, B. and Hansmann, J. and Schulz-Menger, J. and Kelle, S. |
| Abstract: | Myocardial strain is a convenient parameter to quantify left ventricular (LV) function. Fast strain-encoding (fSENC) enables the acquisition of cardiovascular magnetic resonance images for strain-measurement within a few heartbeats during free-breathing. It is necessary to analyze inter-vendor agreement of techniques to determine strain, such as fSENC, in order to compare existing studies and plan multi-center studies. Therefore, the aim of this study was to investigate inter-vendor agreement and test-retest reproducibility of fSENC for three major MRI-vendors. fSENC-images were acquired three times in the same group of 15 healthy volunteers using 3 Tesla scanners from three different vendors: at the German Heart Institute Berlin, the Charité University Medicine Berlin-Campus Buch and the Theresien-Hospital Mannheim. Volunteers were scanned using the same imaging protocol composed of two fSENC-acquisitions, a 15-min break and another two fSENC-acquisitions. LV global longitudinal and circumferential strain (GLS, GCS) were analyzed by a trained observer (Myostrain 5.0, Myocardial Solutions) and for nine volunteers repeatedly by another observer. Inter-vendor agreement was determined using Bland-Altman analysis. Test-retest reproducibility and intra- and inter-observer reproducibility were analyzed using intraclass correlation coefficient (ICC) and coefficients of variation (CoV). Inter-vendor agreement between all three sites was good for GLS and GCS, with biases of 0.01-1.88%. Test-retest reproducibility of scans before and after the break was high, shown by ICC- and CoV values of 0.63-0.97 and 3-9% for GLS and 0.69-0.82 and 4-7% for GCS, respectively. Intra- and inter-observer reproducibility were excellent for both parameters (ICC of 0.77-0.99, CoV of 2-5%). This trial demonstrates good inter-vendor agreement and test-retest reproducibility of GLS and GCS measurements, acquired at three different scanners from three different vendors using fSENC. The results indicate that it is necessary to account for a possible bias (< 2%) when comparing strain measurements of different scanners. Technical differences between scanners, which impact inter-vendor agreement, should be further analyzed and minimized.DRKS Registration Number: 00013253. Universal Trial Number (UTN): U1111-1207-5874. |
| Keywords: | Strain, fSENC, Agreement, Reproducibility, CMR, Cardiac, Magnetic Resonance |
| Source: | International Journal of Cardiovascular Imaging |
| ISSN: | 1569-5794 |
| Publisher: | Springer |
| Volume: | 36 |
| Number: | 5 |
| Page Range: | 899-911 |
| Date: | May 2020 |
| Official Publication: | https://doi.org/10.1007/s10554-020-01775-y |
| PubMed: | View item in PubMed |
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