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Opposite macrophage polarization in different subsets of ovarian cancer: observation from a pilot study

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Item Type:Article
Title:Opposite macrophage polarization in different subsets of ovarian cancer: observation from a pilot study
Creators Name:Vankerckhoven, A., Wouters, R., Mathivet, T., Ceusters, J., Baert, T., Van Hoylandt, A., Gerhardt, H., Vergote, I. and Coosemans, A.
Abstract:The role of the innate immune system in ovarian cancer is gaining importance. The relevance of tumor-associated macrophages (TAM) is insufficiently understood. In this pilot project, comprising the immunofluorescent staining of 30 biopsies taken from 24 patients with ovarian cancer, we evaluated the presence of total TAM (cluster of differentiation (CD) 68 expression), M1 (major histocompatibility complex (MHC) II expression), and M2 (anti-mannose receptor C type 1 (MRC1) expression), and the blood vessel diameter. We observed a high M1/M2 ratio in low-grade ovarian cancer compared to high-grade tumors, more total TAM and M2 in metastatic biopsies, and a further increase in total TAM and M2 at interval debulking, without beneficial effects of bevacizumab. The blood vessel diameter was indicative for M2 tumor infiltration (Spearman correlation coefficient of 0.65). These data mainly reveal an immune beneficial environment in low-grade ovarian cancer in contrast to high-grade serous ovarian cancer, where immune suppression is not altered by neoadjuvant therapy.
Keywords:Ovarian Cancer, Macrophages, M2
Source:Cells
ISSN:2073-4409
Publisher:MDPI
Volume:9
Number:2
Page Range:305
Date:27 January 2020
Official Publication:https://doi.org/10.3390/cells9020305
PubMed:View item in PubMed

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