Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS)

Item Type:	Article
Title:	Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS)
Creators Name:	Scheer, M. and Blank, B. and Bauer, S. and Vokuhl, C. and Stegmaier, S. and Feuchtgruber, S. and Henssen, A. and Sparber-Sauer, M. and Eggert, A. and Handgretinger, R. and Pekrun, A. and Rossig, C. and Rutkowski, S. and Schlegel, P.G. and Schrappe, M. and Simon, T. and Kazanowska, B. and Niggli, F. and Ladenstein, R. and Ljungman, G. and Jahnukainen, K. and Fuchs, J. and Bielack, S.S. and Koscielniak, E. and Klingebiel, T.
Abstract:	BACKGROUND: Older age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown. METHODS: SS patients < 21 years registered in consecutive CWS trials over the period of 1981-2018 were evaluated. Characteristics were analyzed according to age groups using the Fisher's exact test. RESULTS: The study population included 432 SS patients. Disease characteristics differed according to age groups of children (0-12 years, n = 176), adolescents (13-16 years, n = 178), and young adults (17-21 years, n = 78). The proportion of invasive tumors (T2) was significantly higher in older patients: children 33%, adolescents 39% and young adults 54%, p = 0.009805. Similarly, the proportion of tumors > 10 cm was higher (13%, 21%, 31%; p = 0.005657) whereas conversely, the proportion of small tumors < 3 cm was lower in older patients (29%, 24%, 6%; p = 0.000104). The presence of metastases at first diagnosis was also highest in older patients (6%, 10%, 21%, p = 0.000963). Notably, the proportion of thigh tumors was higher in older patients (p = 0.04173), whereas the proportion of head-neck tumors was lower in older patients (p = 0.08896). CONCLUSIONS: The rates of large, invasive tumors and the presence of metastases are significantly associated with older patient age. Localization to the thigh is more frequent in older patients. DISCUSSION: The causes for these variations require further exploration.
Keywords:	Synovial Sarcoma, Soft Tissue Sarcoma, Pediatric Sarcoma, Age, Age Dependency
Source:	Journal of Cancer Research and Clinical Oncology
ISSN:	0171-5216
Publisher:	Springer
Volume:	146
Number:	4
Page Range:	953-960
Date:	April 2020
Official Publication:	https://doi.org/10.1007/s00432-019-03121-9
PubMed:	View item in PubMed

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