Helmholtz Gemeinschaft


Diffusion-weighted renal MRI at 9.4 Tesla using RARE to improve anatomical integrity

PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
[img] MS Word (Supplementary Information)

Item Type:Article
Title:Diffusion-weighted renal MRI at 9.4 Tesla using RARE to improve anatomical integrity
Creators Name:dos Santos Periquito, J. and Paul, K. and Huelnhagen, T. and Ku, M.C. and Ji, Y. and Cantow, K. and Gladytz, T. and Grosenick, D. and Flemming, B. and Seeliger, E. and Waiczies, S. and Niendorf, T. and Pohlmann, A.
Abstract:Diffusion-weighted magnetic resonance imaging (DWI) is a non-invasive imaging technique sensitive to tissue water movement. By enabling a discrimination between tissue properties without the need of contrast agent administration, DWI is invaluable for probing tissue microstructure in kidney diseases. DWI studies commonly make use of single-shot Echo-Planar Imaging (ss-EPI) techniques that are prone to suffering from geometric distortion. The goal of the present study was to develop a robust DWI technique tailored for preclinical magnetic resonance imaging (MRI) studies that is free of distortion and sensitive to detect microstructural changes. Since fast spin-echo imaging techniques are less susceptible to B(0) inhomogeneity related image distortions, we introduced a diffusion sensitization to a split-echo Rapid Acquisition with Relaxation Enhancement (RARE) technique for high field preclinical DWI at 9.4 T. Validation studies in standard liquids provided diffusion coefficients consistent with reported values from the literature. Split-echo RARE outperformed conventional ss-EPI, with ss-EPI showing a 3.5-times larger border displacement (2.60 vs. 0.75) and a 60% higher intra-subject variability (cortex = 74%, outer medulla = 62% and inner medulla = 44%). The anatomical integrity provided by the split-echo RARE DWI technique is an essential component of parametric imaging on the way towards robust renal tissue characterization, especially during kidney disease.
Keywords:Intravoxel Incoherent Motion, Chronic Kidney Disease, Readout Segmented Epi, Low Angle Rare, Single Shot, Spin Echo, Geometric Distortion, Fibrosis, Injury, T(2)*, Animals, Rats
Source:Scientific Reports
Publisher:Nature Publishing Group
Page Range:19723
Date:23 December 2019
Official Publication:https://doi.org/10.1038/s41598-019-56184-6
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library