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| Item Type: | Article |
|---|---|
| Title: | The transcription factor Hey and nuclear lamins specify and maintain cell identity |
| Creators Name: | Flint Brodsly, N. and Bitman-Lotan, E. and Boico, O. and Shafat, A. and Monastirioti, M. and Gessler, M. and Delidakis, C. and Rincon-Arano, H. and Orian, A. |
| Abstract: | The inability of differentiated cells to maintain their identity is a hallmark of age-related diseases. We found that the transcription factor Hey supervises the identity of differentiated enterocytes (ECs) in the adult Drosophila midgut. Lineage tracing established that Hey-deficient ECs are unable to maintain their unique nuclear organization and identity. To supervise cell identity, Hey determines the expression of nuclear lamins, switching from a stem-cell lamin configuration to a differentiated lamin configuration. Moreover, continued Hey expression is required to conserve large-scale nuclear organization. During aging, Hey levels decline, and EC identity and gut homeostasis are impaired, including pathological reprograming and compromised gut integrity. These phenotypes are highly similar to those observed upon acute targeting of Hey or perturbation of lamin expression in ECs in young adults. Indeed, aging phenotypes were suppressed by continued expression of Hey in ECs, suggesting that a Hey-lamin network safeguards nuclear organization and differentiated cell identity. |
| Keywords: | Aging, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Drosophila Proteins, Enterocytes, Lamins, Stem Cells, Animals, Drosophila |
| Source: | eLife |
| ISSN: | 2050-084X |
| Publisher: | eLife Sciences Publications |
| Volume: | 8 |
| Page Range: | e44745 |
| Date: | 16 July 2019 |
| Official Publication: | https://doi.org/10.7554/eLife.44745.001 |
| PubMed: | View item in PubMed |
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