Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Increased expression of endothelial constitutive nitric oxide synthase in rat aorta during pregnancy

Item Type:Article
Title:Increased expression of endothelial constitutive nitric oxide synthase in rat aorta during pregnancy
Creators Name:Goetz, R.M. and Morano, I. and Calovini, T. and Studer, R. and Holtz, J.
Abstract:The mechanisms underlying enhanced vascular reactivity in pregnancy are not yet defined. In this study we have investigated the potential role of endothelium-derived vasodilator nitric oxide (EDNO). EDNO-mediated dilatory responses in vitro were markedly increased in aorta of pregnant as compared with nonpregnant rats. This increase in EDNO-releasability was accompanied by a two-fold increase in mRNA of endothelial constitutive nitric oxide synthase (NOS-III). Chronically substituted estrogen, but neither progesterone nor testosterone induced an upregulation of NOS-III mRNA in aorta of gonadectomized rats which amounted to about half that induced in aorta of pregnant rats. Thus, increased EDNO-releasability and increased NOS-III mRNA contribute to enhanced vascular reactivity in pregnancy.
Keywords:Amino Acid Oxidoreductases, Aorta, Base Sequence, Vascular Endothelium, Estradiol, Enzymologic Gene Expression Regulation, Molecular Sequence Data, Nitric Oxide, Nitric Oxide Synthase, Oligodeoxyribonucleotides, Pregnancy, Messenger RNA, Up-Regulation, Animals, Rats
Source:Biochemical and Biophysical Research Communications
ISSN:0006-291X
Publisher:Academic Press (U.S.A.)
Volume:205
Number:1
Page Range:905-910
Date:30 November 1994
Official Publication:https://doi.org/10.1006/bbrc.1994.2750
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library