Increased expression of endothelial constitutive nitric oxide synthase in rat aorta during pregnancy

Item Type:	Article
Title:	Increased expression of endothelial constitutive nitric oxide synthase in rat aorta during pregnancy
Creators Name:	Goetz, R.M. and Morano, I. and Calovini, T. and Studer, R. and Holtz, J.
Abstract:	The mechanisms underlying enhanced vascular reactivity in pregnancy are not yet defined. In this study we have investigated the potential role of endothelium-derived vasodilator nitric oxide (EDNO). EDNO-mediated dilatory responses in vitro were markedly increased in aorta of pregnant as compared with nonpregnant rats. This increase in EDNO-releasability was accompanied by a two-fold increase in mRNA of endothelial constitutive nitric oxide synthase (NOS-III). Chronically substituted estrogen, but neither progesterone nor testosterone induced an upregulation of NOS-III mRNA in aorta of gonadectomized rats which amounted to about half that induced in aorta of pregnant rats. Thus, increased EDNO-releasability and increased NOS-III mRNA contribute to enhanced vascular reactivity in pregnancy.
Keywords:	Amino Acid Oxidoreductases, Aorta, Base Sequence, Vascular Endothelium, Estradiol, Enzymologic Gene Expression Regulation, Molecular Sequence Data, Nitric Oxide, Nitric Oxide Synthase, Oligodeoxyribonucleotides, Pregnancy, Messenger RNA, Up-Regulation, Animals, Rats
Source:	Biochemical and Biophysical Research Communications
ISSN:	0006-291X
Publisher:	Academic Press
Volume:	205
Number:	1
Page Range:	905-910
Date:	30 November 1994
Official Publication:	https://doi.org/10.1006/bbrc.1994.2750
PubMed:	View item in PubMed

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