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Septins as modulators of endo-lysosomal membrane traffic

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Item Type:Review
Title:Septins as modulators of endo-lysosomal membrane traffic
Creators Name:Song, K. and Russo, G. and Krauss, M.
Abstract:Septins constitute a family of GTP-binding proteins, which assemble into non-polar filaments in a nucleotide-dependent manner. These filaments can be recruited to negatively charged membrane surfaces. When associated with membranes septin filaments can act as diffusion barriers, which confine subdomains of distinct biological functions. In addition, they serve scaffolding roles by recruiting cytosolic proteins and other cytoskeletal elements. Septins have been implicated in a large variety of membrane-dependent processes, including cytokinesis, signaling, cell migration, and membrane traffic, and several family members have been implicated in disease. However, surprisingly little is known about the molecular mechanisms underlying their biological functions. This review summarizes evidence in support of regulatory roles of septins during endo-lysosomal sorting, with a particular focus on phosphoinositides, which serve as spatial landmarks guiding septin recruitment to distinct subcellular localizations.
Keywords:Septins, Membrane, Phosphoinositides, Endocytosis, Endosome, Sorting
Source:Frontiers in Cell and Developmental Biology
Publisher:Frontiers Media SA
Page Range:124
Date:3 November 2016
Official Publication:https://doi.org/10.3389/fcell.2016.00124
PubMed:View item in PubMed

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