Role of Zeb2/Sip1 in neuronal development

Item Type:	Review
Title:	Role of Zeb2/Sip1 in neuronal development
Creators Name:	Epifanova, E. and Babaev, A. and Newman, A.G. and Tarabykin, V.
Abstract:	Zeb2 (Sip1, Zfhx1b) is a transcription factor that plays essential role in neuronal development. Sip1 mutation in humans was shown to cause Mowat-Wilson syndrome, a syndromic form of Hirschprung's disease. Affected individuals exhibit multiple severe neurodevelopmental defects. Zeb2 can act as both transcriptional repressor and activator. It controls expression of a wide number of genes that regulate various aspects of neuronal development. This review addresses the molecular pathways acting downstream of Zeb2 that cause brain development disorders.
Keywords:	Brain Development, Cortex, Hippocampus, Mowat-Wilson Syndrome
Source:	Brain Research
ISSN:	0006-8993
Publisher:	Elsevier
Volume:	1705
Page Range:	24-31
Date:	15 February 2019
Official Publication:	https://doi.org/10.1016/j.brainres.2018.09.034
PubMed:	View item in PubMed

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