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Role of Zeb2/Sip1 in neuronal development

Item Type:Review
Title:Role of Zeb2/Sip1 in neuronal development
Creators Name:Epifanova, E. and Babaev, A. and Newman, A.G. and Tarabykin, V.
Abstract:Zeb2 (Sip1, Zfhx1b) is a transcription factor that plays essential role in neuronal development. Sip1 mutation in humans was shown to cause Mowat-Wilson syndrome, a syndromic form of Hirschprung's disease. Affected individuals exhibit multiple severe neurodevelopmental defects. Zeb2 can act as both transcriptional repressor and activator. It controls expression of a wide number of genes that regulate various aspects of neuronal development. This review addresses the molecular pathways acting downstream of Zeb2 that cause brain development disorders.
Keywords:Brain Development, Cortex, Hippocampus, Mowat-Wilson Syndrome
Source:Brain Research
Page Range:24-31
Date:15 February 2019
Official Publication:https://doi.org/10.1016/j.brainres.2018.09.034
PubMed:View item in PubMed

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