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Deconstructing age reprogramming

Item Type:Review
Title:Deconstructing age reprogramming
Creators Name:Singh, P.B. and Laktionov, P.P. and Newman, A.G.
Abstract:It has been proposed that age reprogramming enables old cells to be rejuvenated without passage through an embryonic stage (Singh and Zacouto in J. Biosci. 35 315-319, 2010). As such, age reprogramming stands apart from the induced pluripotent stem (iPS) and nuclear transfer-embryonic stem (NT-ES) cell therapies where histo-compatible cells are produced only after passage through an embryonic stage. It avoids many of the disadvantages associated with iPS and NT-ES cell therapies. Experimental evidence in support of age reprogramming is burgeoning. Here, we discuss possible new approaches to enhance age reprogramming, which will have considerable benefits for regenerative therapies.
Keywords:Age Reprogramming, Epigenetic Rejuvenation, iPS Cells, Reprogramming Factors, Epigenetic Clock, eAge
Source:Journal of Biosciences
Publisher:Indian Academy of Sciences
Page Range:106
Date:September 2019
Official Publication:https://doi.org/10.1007/s12038-019-9923-1
PubMed:View item in PubMed

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