Deconstructing age reprogramming

Tools

Item Type:	Review
Title:	Deconstructing age reprogramming
Creators Name:	Singh, P.B., Laktionov, P.P. and Newman, A.G.
Abstract:	It has been proposed that age reprogramming enables old cells to be rejuvenated without passage through an embryonic stage (Singh and Zacouto in J. Biosci. 35 315-319, 2010). As such, age reprogramming stands apart from the induced pluripotent stem (iPS) and nuclear transfer-embryonic stem (NT-ES) cell therapies where histo-compatible cells are produced only after passage through an embryonic stage. It avoids many of the disadvantages associated with iPS and NT-ES cell therapies. Experimental evidence in support of age reprogramming is burgeoning. Here, we discuss possible new approaches to enhance age reprogramming, which will have considerable benefits for regenerative therapies.
Keywords:	Age Reprogramming, Epigenetic Rejuvenation, iPS Cells, Reprogramming Factors, Epigenetic Clock, eAge
Source:	Journal of Biosciences
ISSN:	0250-5991
Publisher:	Indian Academy of Sciences
Volume:	44
Number:	4
Page Range:	106
Date:	September 2019
Official Publication:	https://doi.org/10.1007/s12038-019-9923-1
PubMed:	View item in PubMed

Repository Staff Only: item control page