Helmholtz Gemeinschaft


Serotonylation: serotonin signaling and epigenetics

PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader

Item Type:Review
Title:Serotonylation: serotonin signaling and epigenetics
Creators Name:Bader, M.
Abstract:Serotonylation, the covalent linkage of serotonin to proteins has been discovered more than 60 years ago but only recently the mechanisms and first functions have been elucidated. It has been found that transglutaminases (TG) such as TG2 and the blood coagulation factor XIIIa are the enzymes which catalyze the linkage of serotonin and other monoamines to distinct glutamine (Gln) residues of target proteins. The first target proteins, small G-proteins and extracellular matrix constituents, were found in platelets and are pivotally involved in platelet aggregation and the formation of thrombi. The serotonylation of the same proteins is also involved in insulin secretion and in the proliferation of pulmonary vascular smooth muscle cells and thereby in the pathogenesis of pulmonary arterial hypertension (PAH). Recently histones have been described as targets of serotonylation opening the area of transcriptional control to this posttranslational protein modification. Future studies will certainly reveal further target proteins, signaling pathways, cellular processes, and diseases, in which serotonylation or, more general, monoaminylation is important.
Keywords:Serotonin, Histone, G-Protein, Protein Modification, Pulmonary Hypertension, Epigenetics, Monoaminylation, Transglutaminase
Source:Frontiers in Molecular Neuroscience
Publisher:Frontiers Media SA
Page Range:288
Date:21 November 2019
Official Publication:https://doi.org/10.3389/fnmol.2019.00288
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library