Cellular senescence: defining a path forward

Item Type:	Review
Title:	Cellular senescence: defining a path forward
Creators Name:	Gorgoulis, V. and Adams, P.D. and Alimonti, A. and Bennett, D.C. and Bischof, O. and Bishop, C. and Campisi, J. and Collado, M. and Evangelou, K. and Ferbeyre, G. and Gil, J. and Hara, E. and Krizhanovsky, V. and Jurk, D. and Maier, A.B. and Narita, M. and Niedernhofer, L. and Passos, J.F. and Robbins, P.D. and Schmitt, C.A. and Sedivy, J. and Vougas, K. and von Zglinicki, T. and Zhou, D. and Serrano, M. and Demaria, M.
Abstract:	Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.
Keywords:	Aging, Biomarkers, Cell Cycle Checkpoints, Cellular Senescence, Chromatin, Gene Expression Regulation, Inborn Genetic Diseases
Source:	Cell
ISSN:	0092-8674
Publisher:	Cell Press
Volume:	179
Number:	4
Page Range:	813-827
Date:	31 October 2019
Additional Information:	Copyright © 2019 Elsevier Inc.
Official Publication:	https://doi.org/10.1016/j.cell.2019.10.005
External Fulltext:	View full text on external repository or document server
PubMed:	View item in PubMed

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