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Analysis of NTRK expression in gastric and esophageal adenocarcinoma (AGE) with pan-TRK immunohistochemistry

Item Type:Article
Title:Analysis of NTRK expression in gastric and esophageal adenocarcinoma (AGE) with pan-TRK immunohistochemistry
Creators Name:Arnold, A. and Daum, S. and von Winterfeld, M. and Berg, E. and Hummel, M. and Horst, D. and Rau, B. and Stein, U. and Treese, C.
Abstract:Small molecule inhibitors such as Larotrectinib have been recently approved in the treatment of patients with fusions of the neurotrophic-tropomyosin receptor tyrosine kinase (NTRK) genes 1-3. These genomic rearrangements have been reported across different tumor subtypes with a high prevalence in rare tumors. However, in gastric and esophageal adenocarcinoma (AGE) NTRK fusions have also been described in a subset of Asian patients. In order to study the prevalence of this alteration in Caucasian patients with AGE we performed immunohistochemistry for pan-NTRK in 438 formalin-fixed paraffin embedded (FFPE) tumor samples. While we found NTRK expression in gastric glands and tumor adjacent nerve tissue, we did not detect this marker in the tumor compartment. Based on our findings NTRK fusions do not seem to play a role in the molecularpathology of Caucasian AEG patients, so that other treatment options are required.
Keywords:Neurotrophic-Tropomyosin Receptor Tyrosine Kinase (NTRK) Gene Fusion, Gastric and Esophageal Adenocarcinoma (AGE), Larotrectinib
Source:Pathology Research and Practice
ISSN:0344-0338
Publisher:Elsevier (Germany)
Volume:215
Number:11
Page Range:152662
Date:November 2019
Official Publication:https://doi.org/10.1016/j.prp.2019.152662
PubMed:View item in PubMed

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