Angiotensin II type 2 receptor mediates high fat diet-induced cardiomyocyte hypertrophy and hypercholesterolemia

Item Type:	Article
Title:	Angiotensin II type 2 receptor mediates high fat diet-induced cardiomyocyte hypertrophy and hypercholesterolemia
Creators Name:	Lima, V.M. and Lino, C.A. and Senger, N. and de Oliveira Silva, T. and Fonseca, R.I.B. and Bader, M. and Santos, R.A.S. and Júnior, JD. and Barreto-Chaves, M.L.M. and Diniz, G.P.
Abstract:	Obesity is the major risk factor for several cardiovascular and metabolic disorders. Previous studies reported that deletion of Angiotensin II type 2 receptor (AT2R) protects against metabolic dysfunctions induced by high fat (HF) diet. However, the role of AT2R in obesity-induced cardiac hypertrophy remains unclear. Male AT2R knockout (AT2RKO) and wild type (AT2RWT) mice were fed with control or HF diet for 10 weeks. HF diet increased cardiac expression of AT2R in obese mice. Deletion of AT2R did not affect body weight gain, glucose intolerance and fat mass gain induced by HF feeding. However, loss of AT2R prevented HF diet-induced hypercholesterolemia and cardiac remodeling. Mechanistically, we found that pharmacological inhibition or knockdown of AT2R prevented leptin-induced cardiomyocyte hypertrophy in vitro. Collectively, our results suggest that AT2R is involved in obesity-induced cardiac hypertrophy.
Keywords:	Angiotensin II Type 2 Receptor, Cardiomyocyte Hypertrophy, High Fat Diet, Obesity, Animals, Mice
Source:	Molecular and Cellular Endocrinology
ISSN:	0303-7207
Publisher:	Elsevier
Volume:	498
Page Range:	110576
Date:	1 December 2019
Official Publication:	https://doi.org/10.1016/j.mce.2019.110576
PubMed:	View item in PubMed

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