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The role of AKAP12 in coordination of VEGF-induced endothelial cell motility

Item Type:Editorial
Title:The role of AKAP12 in coordination of VEGF-induced endothelial cell motility
Creators Name:Walker-Gray, R. and Klussmann, E.
Abstract:In this issue of Acta Physiologica, Benz et al. study the role of one important protein in the cyclic AMP signaling pathway, the A-kinase anchoring (AKAP)12. The downstream effects stemming from cAMP release are tightly controlled and activate a profusion of signaling pathways. However, many of these different processes function with largely the same major constituent proteins, including adenylate cyclases, kinases, phosphatases, and phosphodiesterases. cAMP-dependent protein kinase (PKA), which is the main intracellular target for cAMP, is widely found in these signaling assemblies, and is present at high concentrations in many tissues, playing varied roles in the regulation of molecular processes. Unexpectedly, despite its ubiquity there are only four isoforms of PKA regulatory subunit with which to impart functional and locational specificity.
Source:Acta Physiologica
ISSN:1748-1708
Publisher:Wiley (U.S.A.)
Date:10 August 2019
Official Publication:https://doi.org/10.1111/apha.13359
PubMed:View item in PubMed

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