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Pathophysiological role of caveolae in hypertension

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Item Type:Review
Title:Pathophysiological role of caveolae in hypertension
Creators Name:Lian, X. and Matthaeus, C. and Kaßmann, M. and Daumke, O. and Gollasch, M.
Abstract:Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1-4, EHD2, pacsin2, and dynamin 2. Caveolae participate in several physiological processes like lipid uptake, mechanosensitivity, or signaling events and are involved in pathophysiological changes in the cardiovascular system. They serve as a specific membrane platform for a diverse set of signaling molecules like endothelial nitric oxide synthase (eNOS), and further maintain vascular homeostasis. Lack of caveolins causes the complete loss of caveolae; induces vascular disorders, endothelial dysfunction, and impaired myogenic tone; and alters numerous cellular processes, which all contribute to an increased risk for hypertension. This brief review describes our current knowledge on caveolae in vasculature, with special focus on their pathophysiological role in hypertension.
Keywords:Caveolae, Caveolin 1, Endothelial Nitric Oxide Synthase, Ca(2+) Channels, Hypertension
Source:Frontiers in Medicine
ISSN:2296-858X
Publisher:Frontiers Media (Switzerland)
Volume:6
Page Range:153
Date:July 2019
Official Publication:https://doi.org/10.3389/fmed.2019.00153
PubMed:View item in PubMed

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