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Diagnostik und Therapie von Tuberkulose unter Immuntherapien für Multiple Sklerose : aktueller Stand und Empfehlungen in Deutschland [Diagnostics and treatment of tuberculosis under immunotherapy for multiple sclerosis : current status and recommendations in Germany]

Item Type:Review
Title:Diagnostik und Therapie von Tuberkulose unter Immuntherapien für Multiple Sklerose : aktueller Stand und Empfehlungen in Deutschland [Diagnostics and treatment of tuberculosis under immunotherapy for multiple sclerosis : current status and recommendations in Germany]
Creators Name:Bittner, S. and Engel, S. and Lange, C. and Weber, M.S. and Haghikia, A. and Luessi, F. and Korn, T. and Klotz, L. and Bayas, A. and Paul, F. and Heesen, C. and Stangel, M. and Wildemann, B. and Bergh, F.T. and Tackenberg, B. and Trebst, C. and Warnke, C. and Linker, R. and Kerschensteiner, M. and Zettl, U. and Tumani, H. and Brück, W. and Meuth, S.G. and Kümpfel, T. and Hemmer, B. and Wiendl, H. and Gold, R. and Zipp, F.
Abstract:After years of low incidence, a large increase of new tuberculosis (TB) cases has been reported in Germany since 2015. New immunotherapies for the treatment of multiple sclerosis (MS) are associated with a reduced immune competence and a potential increased risk for infections. Most neurologists lack specific experiences with TB infections. This article summarizes specific recommendations for the diagnostics and treatment of TB under MS immunotherapies with a focus on the situation in Germany. Due to low case numbers and little experience with the risk of TB under the new immunotherapies, the clinical competence network for MS (KKNMS) consensus recommendations have a low grade of evidence.
Keywords:Multiple Sclerosis, Treatment, Immune Monitoring, Tuberculosis, Prevention
Source:Nervenarzt
ISSN:0028-2804
Publisher:Springer (Germany)
Volume:90
Number:12
Page Range:1245-1253
Date:December 2019
Official Publication:https://doi.org/10.1007/s00115-019-0760-0
PubMed:View item in PubMed

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