![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
442kB |
![[thumbnail of Supporting Information]](https://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Supporting Information)
22MB |
| Item Type: | Article |
|---|---|
| Title: | Cerebral microbleeds are not associated with postoperative delirium and postoperative cognitive dysfunction in older individuals |
| Creators Name: | Lachmann, G., Kant, I., Lammers, F., Windmann, V., Spies, C., Speidel, S., Borchers, F., Hadzidiakos, D., Hendrikse, J., Winterer, G. and de Bresser, J. |
| Abstract: | BACKGROUND: Cerebral microbleeds (CMB) occur in the context of cerebral small vessel disease. Other brain MRI markers of cerebral small vessel disease are associated with the occurrence of postoperative delirium (POD) and postoperative cognitive dysfunction (POCD), but for CMB this is unknown. We aimed to study the association between CMB and the occurrence of POD and POCD in older individuals. METHODS: The current study consists of 65 patients (72±5 years) from the BIOCOG study, which is a prospective, observational study of patients who underwent an elective surgery of at least 60 minutes. Patients in the current study received a preoperative cerebral MRI scan including a 3D susceptibility-weighted imaging sequence to detect CMB. The occurrence of POD was screened for twice a day until postoperative day 7 by using the DSM-5, NuDesc, CAM, and CAM-ICU. The occurrence of POCD was determined by the reliable change index model at 7 days after surgery or discharge, respectively, and 3 months after surgery. Statistical analyses consisted of logistic regression adjusted for age and gender. RESULTS: A total of 39 CMB were detected in 17 patients (26%) prior to surgery. POD occurred in 14 out of 65 patients (22%). POCD at 7 days after surgery occurred in 11 out of 54 patients (20%) and in 3 out of 40 patients at the 3 month follow-up (8%). Preoperative CMB were not associated with the occurrence of POD (OR (95%-CI): 0.28 (0.05, 1.57); p = 0.147) or POCD at 7 days after surgery (0.76 (0.16, 3.54); p = 0.727) or at 3 months follow-up (0.61 (0.03, 11.64); p = 0.740). CONCLUSION: We did not find an association between preoperative CMB and the occurrence of POD or POCD. TRIAL REGISTRATION: clinicaltrials.gov (NCT02265263) on 23 September 2014. |
| Keywords: | Age Factors, Biomarkers, Cerebral Hemorrhage, Computer-Assisted Image Processing, Delirium, Magnetic Resonance Imaging, Odds Ratio, Postoperative Cognitive Complications, Three-Dimensional Imaging |
| Source: | PLoS ONE |
| ISSN: | 1932-6203 |
| Publisher: | Public Library of Science |
| Volume: | 14 |
| Number: | 6 |
| Page Range: | e0218411 |
| Date: | 14 June 2019 |
| Additional Information: | Tobias Pischon is a member of the BIOCOG Consortium. |
| Official Publication: | https://doi.org/10.1371/journal.pone.0218411 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
