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Cardiorenal (23)Na MRI at 7.0 Tesla using a 4/4 channel (1)H/(23)Na RF antenna array

Item Type:Article
Title:Cardiorenal (23)Na MRI at 7.0 Tesla using a 4/4 channel (1)H/(23)Na RF antenna array
Creators Name:Boehmert, L. and Kuehne, A. and Waiczies, H. and Wenz, D. and Eigentler, T.W. and Funk, S. and von Knobelsdorff-Brenkenhoff, F. and Schulz-Menger, J. and Nagel, A.M. and Seeliger, E. and Niendorf, T.
Abstract:PURPOSE: Cardiorenal syndrome describes disorders of the heart and the kidneys in which a dysfunction of 1 organ induces a dysfunction in the other. This work describes the design, evaluation, and application of a 4/4-channel hydrogen-1/sodium ((1)H/(23)Na) RF array tailored for cardiorenal MRI at 7.0 Tesla (T) for a better physiometabolic understanding of cardiorenal syndrome. METHODS: The dual-frequency RF array is composed of a planar posterior section and a modestly curved anterior section, each section consisting of 2 loop elements tailored for (23)Na MR and 2 loopole-type elements customized for (1)H MR. Numerical electromagnetic field and specific absorption rate simulations were carried out. Transmission field (B(1)(+)) uniformity was optimized and benchmarked against electromagnetic field simulations. An in vivo feasibility study was performed. RESULTS: The proposed array exhibits sufficient RF characteristics, B(1)(+) homogeneity, and penetration depth to perform (23)Na MRI of the heart and kidney at 7.0 T. The mean B(1)(+) field for sodium in the heart is 7.7 ± 0.8 µT/√kW and in the kidney is 6.9 ± 2.3 µT/√kW. The suitability of the RF array for (23)Na MRI was demonstrated in healthy subjects (acquisition time for (23)Na MRI: 18 min; nominal isotropic spatial resolution: 5 mm [kidney] and 6 mm [heart]). CONCLUSION: This work provides encouragement for further explorations into densely packed multichannel transceiver arrays tailored for (23)Na MRI of the heart and kidney. Equipped with this technology, the ability to probe sodium concentration in the heart and kidney in vivo using (23)Na MRI stands to make a critical contribution to deciphering the complex interactions between both organs.
Keywords:Cardiac MRI, Cardiorenal Syndrome, MRI, Renal MRI, RF Coil, Sodium
Source:Magnetic Resonance in Medicine
ISSN:0740-3194
Publisher:Wiley (U.S.A.)
Volume:82
Number:6
Page Range:2343-2356
Date:December 2019
Official Publication:https://doi.org/10.1002/mrm.27880
PubMed:View item in PubMed

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