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Cognitive impairment in neuromyelitis optica spectrum disorders: a review of clinical and neuroradiological features

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Item Type:Review
Title:Cognitive impairment in neuromyelitis optica spectrum disorders: a review of clinical and neuroradiological features
Creators Name:Oertel, F.C. and Schließeit, J. and Brandt, A.U. and Paul, F.
Abstract:Neuromyelitis optica spectrum disorders (NMOSD) are mostly relapsing autoimmune inflammatory disorders of the central nervous system (CNS) with optic neuritis, myelitis, and brainstem syndromes as clinical hallmarks. With a reported prevalence of up to 70%, cognitive impairment is frequent, but often unrecognized and an insufficiently treated burden of the disease. The most common cognitive dysfunctions are decline in attention and memory performance. Magnetic resonance imaging can be used to access structural correlates of neuropsychological disorders. Cognitive impairment is not only a highly underestimated symptom in patients with NMOSD, but potentially also a clinical correlate of attack-independent changes in NMOSD, which are currently under debate. This article reviews cognitive impairment in NMOSD and discusses associations between structural changes of the CNS and cognitive deficits.
Keywords:Neuromyelitis Optica Spectrum Disorders, Cognition, Neuroinflammation, Advanced Imaging, MRI
Source:Frontiers in Neurology
ISSN:1664-2295
Publisher:Frontiers Research Foundation (Switzerland)
Volume:10
Page Range:608
Date:12 June 2019
Official Publication:https://doi.org/10.3389/fneur.2019.00608
PubMed:View item in PubMed

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