Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

High salt inhibits tumor growth by enhancing anti-tumor immunity

[thumbnail of Original Article]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
2MB
[thumbnail of Supplement]
Preview
PDF (Supplement) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
4MB

Item Type:Article
Title:High salt inhibits tumor growth by enhancing anti-tumor immunity
Creators Name:Willebrand, R., Hamad, I., Van Zeebroeck, L., Kiss, M., Bruderek, K., Geuzens, A., Swinnen, D., Côrte-Real, B.F., Markó, L., Lebegge, E., Laoui, D., Kemna, J., Kammertoens, T., Brandau, S., Van Ginderachter, J.A. and Kleinewietfeld, M.
Abstract:Excess salt intake could affect the immune system by shifting the immune cell balance toward a pro-inflammatory state. Since this shift of the immune balance is thought to be beneficial in anti-cancer immunity, we tested the impact of high salt diets on tumor growth in mice. Here we show that high salt significantly inhibited tumor growth in two independent murine tumor transplantation models. Although high salt fed tumor-bearing mice showed alterations in T cell populations, the effect seemed to be largely independent of adaptive immune cells. In contrast, depletion of myeloid-derived suppressor cells (MDSCs) significantly reverted the inhibitory effect on tumor growth. In line with this, high salt conditions almost completely blocked murine MDSC function in vitro. Importantly, similar effects were observed in human MDSCs isolated from cancer patients. Thus, high salt conditions seem to inhibit tumor growth by enabling more pronounced anti-tumor immunity through the functional modulation of MDSCs. Our findings might have critical relevance for cancer immunotherapy.
Keywords:Cancer, Dietary Factor, MDSC, Cancer Immunotherapy, Sodium Chloride (Dietary), Animals, Mice
Source:Frontiers in Immunology
ISSN:1664-3224
Publisher:Frontiers Media SA
Volume:10
Page Range:1141
Date:4 June 2019
Official Publication:https://doi.org/10.3389/fimmu.2019.01141
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library