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Pregnancy galectinology: insights into a complex network of glycan binding proteins

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Item Type:Review
Title:Pregnancy galectinology: insights into a complex network of glycan binding proteins
Creators Name:Blois, S.M. and Dveksler, G. and Vasta, G.R. and Freitag, N. and Blanchard, V. and Barrientos, G.
Abstract:Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.
Keywords:Galectins, Pregnancy, Placentation, Glycans, Preeclampsia, Animals
Source:Frontiers in Immunology
Publisher:Frontiers Media SA
Page Range:1166
Date:May 2019
Official Publication:https://doi.org/10.3389/fimmu.2019.01166
PubMed:View item in PubMed

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