Helmholtz Gemeinschaft


Olfactory and gustatory dysfunction in patients with autoimmune encephalitis

PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader

Item Type:Article
Title:Olfactory and gustatory dysfunction in patients with autoimmune encephalitis
Creators Name:Geran, R. and Uecker, F.C. and Prüss, H. and Haeusler, K.G. and Paul, F. and Ruprecht, K. and Harms, L. and Schmidt, F.A.
Abstract:OBJECTIVE: To test the hypothesis that olfactory (OF) and gustatory function (GF) is disturbed in patients with autoimmune encephalitides (AE). METHODS: The orthonasal OF was tested in 32 patients with AE and 32 age- and sex-matched healthy controls (HC) with the standardized Threshold Discrimination Identification (TDI) score. This validated olfactory testing method yields individual scores for olfactory threshold (T), odor discrimination (D), and identification (I), along with a composite TDI score. The GF was determined by the Taste Strip Test (TST). RESULTS: Overall, 24/32 (75%) of patients with AE, but none of 32 HC (p < 0.001) had olfactory dysfunction in TDI testing. The results of the threshold, discrimination and identification subtests were significantly reduced in patients with AE compared to HC (all p < 0.001). Assessed by TST, 5/19 (26.3%) of patients with AE, but none of 19 HC presented a significant limitation in GF (p < 0.001). The TDI score was correlated with the subjective estimation of the olfactory capacity on a visual analog scale (VAS; r(s) = 0.475, p = 0.008). Neither age, sex, modified Rankin Scale nor disease duration were associated with the composite TDI score. CONCLUSIONS: This is the first study investigating OF and GF in AE patients. According to unblinded assessment, patients with AE have a reduced olfactory and gustatory capacity compared to HC, suggesting that olfactory and gustatory dysfunction are hitherto unrecognized symptoms in AE. Further studies with larger number of AE patients would be of interest to verify our results.
Keywords:Autoimmune Encephalitis, Olfactory Dysfunction, Gustatory Dysfunction, Olfactory Testing, Threshold Discrimination Identification Test
Source:Frontiers in Neurology
Publisher:Frontiers Media SA
Page Range:480
Date:May 2019
Official Publication:https://doi.org/10.3389/fneur.2019.00480
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library