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A (3D-nuclear) space odyssey: making sense of Hi-C maps

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Item Type:Review
Title:A (3D-nuclear) space odyssey: making sense of Hi-C maps
Creators Name:Mota-Gómez, I. and Lupiáñez, D.G.
Abstract:Three-dimensional 3D)-chromatin organization is critical for proper enhancer-promoter communication and, therefore, for a precise execution of the transcriptional programs governing cellular processes. The emergence of Chromosome Conformation Capture (3C) methods, in particular Hi-C, has allowed the investigation of chromatin interactions on a genome-wide scale, revealing the existence of overlapping molecular mechanisms that we are just starting to decipher. Therefore, disentangling Hi-C signal into these individual components is essential to provide meaningful biological data interpretation. Here, we discuss emerging views on the molecular forces shaping the genome in 3D, with a focus on their respective contributions and interdependence. We discuss Hi-C data at both population and single-cell levels, thus providing criteria to interpret genomic function in the 3D-nuclear space.
Keywords:3D-Chromatin Organization, Long-Range Gene Regulation, Chromosome Conformation Capture
Source:Genes
ISSN:2073-4425
Publisher:MDPI (Switzerland)
Volume:10
Number:6
Page Range:415
Date:29 May 2019
Official Publication:https://doi.org/10.3390/genes10060415
PubMed:View item in PubMed

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