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| Item Type: | Article |
|---|---|
| Title: | Regulatory antibodies against GPCR in women ten years after early-onset preeclampsia |
| Creators: |
Birukov, A.  ORCID: https://orcid.org/0000-0002-8306-3351, Muijsers, H.E.C., Heidecke, H., Drost, J.T., Cunnigham, M.W., Kraker, K. ORCID: https://orcid.org/0000-0002-4032-5382, Haase, N. ORCID: https://orcid.org/0000-0003-0727-1738, Frolova, A. ORCID: https://orcid.org/0000-0001-5469-7366, Müller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644, Herse, F. ORCID: https://orcid.org/0000-0002-9305-8134, Maas, A.H.E.M. and Dechend, R. ORCID: https://orcid.org/0000-0001-6636-3080
|
| Abstract: | Preeclampsia is associated with an increased cardiovascular risk later in life. Anti-GPCR autoantibodies have been shown to contribute to the development of cardiovascular disease. We investigated whether anti-GPCR autoantibodies are elevated in women with a history of early-onset preeclampsia 8-11 years postpartum, and whether they correlate with clinical outcomes. We investigated data from the Preeclampsia Risk EValuation in FEMales cohort, a retrospective matched case-control study. Anti AT1R-, beta1AR-, ETAR-, PAR1- and CXCR3- autoantibodies were determined in 485 samples by using commercially available ELISA. Women with the lowest combined levels of autoantibodies and a history of early preeclampsia had significantly higher SBP, DBP and MAP (all p<0.001) compared to the controls. The individual titer levels of autoantibodies were not different between controls and former early PE groups 8-11 years postpartum. In conclusion, regulatory autoantibodies alone are not sufficient to explain hypertension or other cardiovascular pathologic conditions, but together with other risk factors such as a previous hypertensive pregnancy, lower levels of autoantibodies are associated with increased blood pressure. |
| Keywords: | Autoantibodies Against GPCR, Preeclampsia, Adverse Pregnancy Outcome, Blood Pressure, Cardiovascular Risk |
| Source: | Frontiers in Bioscience |
| ISSN: | 1093-9946 |
| Publisher: | Frontiers in Bioscience |
| Volume: | 24 |
| Page Range: | 1462-1476 |
| Date: | 1 June 2019 |
| Official Publication: | https://doi.org/10.2741/4791 |
| PubMed: | View item in PubMed |
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