Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses' Health Study II

Item Type:	Article
Title:	Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses' Health Study II
Creators Name:	de Rezende, L.F.M. and Lee, D.H. and Keum, N.N. and Nimptsch, K. and Song, M. and Lee, I.M. and Eluf-Neto, J. and Ogino, S. and Fuchs, C. and Meyerhardt, J. and Chan, A.T. and Willett, W. and Giovannucci, E. and Wu, K.
Abstract:	BACKGROUND: Physical activity during adulthood has been consistently associated with lower risk of colorectal cancers, but whether physical activity during adolescence may also play a role in colorectal carcinogenesis is unclear. METHODS: We included 28,250 women in the Nurses' Health Study II who provided data on physical activity during adolescence (ages 12–22 years) in 1997 and underwent lower bowel endoscopy (1998–2011). We used logistic regression models for clustered data to examine the association between physical activity during adolescence and risk of adenoma later in life. RESULTS: Physical activity during adolescence was inversely associated with risk of colorectal adenoma (2373 cases), independent of physical activity during adulthood. The multivariable-adjusted odds ratio (OR) of adenoma was 0.89 (95% CI 0.77–1.02; P(trend) = 0.03) comparing women with ≥ 72 metabolic equivalent of tasks-hours/week (MET-h/week) to < 21 MET-h/week. Women with high physical activity during both adolescence (≥53.3 MET-h/week) and adulthood (≥23.1 MET-h/week) had significantly lower risk of adenoma (all adenomas: OR 0.76; 95% CI 0.66–0.88; advanced adenoma: OR 0.61; 95% CI 0.45–0.82) compared to women with low physical activity during both stages of life. CONCLUSIONS: Our findings suggest that physical activity during adolescence may lower the risk of colorectal adenoma later in life.
Keywords:	Adenoma, Colorectal Neoplasms, Exercise, Logistic Models, Prospective Studies, Risk
Source:	British Journal of Cancer
ISSN:	0007-0920
Publisher:	Nature Publishing Group
Volume:	121
Number:	1
Page Range:	86-94
Date:	July 2019
Additional Information:	This article will also be available in Open Access at PubMed Central with a delayed release (embargo) on November 19, 2020.
Official Publication:	https://doi.org/10.1038/s41416-019-0454-1
External Fulltext:	View full text on PubMed Central
PubMed:	View item in PubMed

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