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Emergence of robust nucleosome patterns from an interplay of positioning mechanisms

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Item Type:Preprint
Title:Emergence of robust nucleosome patterns from an interplay of positioning mechanisms
Creators Name:Nuebler, J. and Wolff, M. and Obermayer, B. and Mobius, W. and Gerland, U.
Abstract:Proper positioning of nucleosomes in eukaryotic cells is determined by a complex interplay of factors, including nucleosome-nucleosome interactions, DNA sequence, and active chromatin remodeling. Yet, characteristic features of nucleosome positioning, such as geneaveraged nucleosome patterns, are surprisingly robust across perturbations, conditions, and species. Here, we explore how this robustness arises despite the underlying complexity. We leverage mathematical models to show that a large class of positioning mechanisms merely affects the quantitative characteristics of qualitatively robust positioning patterns. We demonstrate how statistical positioning emerges as an effective description from the complex interplay of different positioning mechanisms, which ultimately only renormalize the model parameter quantifying the effective softness of nucleosomes. This renormalization can be species-specific, rationalizing a puzzling discrepancy between the effective nucleosome softness of S. pombe and S. cerevisiae. More generally, we establish a quantitative framework for dissecting the interplay of different nucleosome positioning determinants.
Keywords:Nucleosome Positioning, Chromatin, Remodeling Enzymes
Source:bioRxiv
Publisher:Cold Spring Harbor Laboratory Press (U.S.A.)
Article Number:431445
Date:1 October 2018
Official Publication:https://doi.org/10.1101/431445

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