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| Item Type: | Article |
|---|---|
| Title: | Standardization of T1w/T2w ratio improves detection of tissue damage in multiple sclerosis |
| Creators Name: | Cooper, G. and Finke, C. and Chien, C. and Brandt, A.U. and Asseyer, S. and Ruprecht, K. and Bellmann-Strobl, J. and Paul, F. and Scheel, M. |
| Abstract: | Normal appearing white matter (NAWM) damage develops early in multiple sclerosis (MS) and continues in the absence of new lesions. The ratio of T1w and T2w (T1w/T2w ratio), a measure of white matter integrity, has previously shown reduced intensity values in MS NAWM. We evaluate the validity of a standardized T1w/T2w ratio (sT1w/T2w ratio) in MS and whether this method is sensitive in detecting MS-related differences in NAWM. T1w and T2w scans were acquired at 3 Tesla in 47 patients with relapsing-remitting MS and 47 matched controls (HC). T1w/T2w and sT1w/T2w ratios were then calculated. We compared between-group variability between T1w/T2w and sT1w/T2w ratio in HC and MS and assessed for group differences. We also evaluated the relationship between the T1w/T2w and sT1w/T2w ratios and clinically relevant variables. Compared to the classic T1w/T2w ratio, the between-subject variability in sT1w/T2w ratio showed a significant reduction in MS patients (p < 0.001) and HC (p < 0.001). However, only sT1w/T2w ratio values were reduced in patients compared to HC (p < 0.001). The sT1w/T2w ratio intensity values were significantly influenced by age, T2 lesion volume and group status (MS vs. HC) (adjusted R(2) = 0.30, p < 0.001). We demonstrate the validity of the sT1w/T2w ratio in MS and that it is more sensitive to MS-related differences in NAWM compared to T1w/T2w ratio. The sT1w/T2w ratio shows promise as an easily-implemented measure of NAWM in MS using readily available scans and simple post-processing methods. |
| Keywords: | Magnetic Resonance Imaging Techniques, Multiple Sclerosis, Normal Appearing White Matter, T1w/T2w Ratio, Relapsing-Remitting |
| Source: | Frontiers in Neurology |
| ISSN: | 1664-2295 |
| Publisher: | Frontiers Media SA |
| Volume: | 10 |
| Page Range: | 334 |
| Date: | April 2019 |
| Official Publication: | https://doi.org/10.3389/fneur.2019.00334 |
| PubMed: | View item in PubMed |
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