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Interplay of Na(+) balance and immunobiology of dendritic cells

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Item Type:Review
Title:Interplay of Na(+) balance and immunobiology of dendritic cells
Creators Name:Neubert, P. and Schröder, A. and Müller, D.N. and Jantsch, J.
Abstract:Local Na(+) balance emerges as an important factor of tissue microenvironment. On the one hand, immune cells impact on local Na(+) levels. On the other hand, Na(+) availability is able to influence immune responses. In contrast to macrophages, our knowledge of dendritic cells (DCs) in this state of affair is rather limited. Current evidence suggests that the impact of increased Na(+) on DCs is context dependent. Moreover, it is conceivable that DC immunobiology might also be influenced by Na(+)-rich-diet-induced changes of the gut microbiome.
Keywords:Dendritic Cells, Na(+) Balance, Antigen-Presentation, Nfat5, Kidney, Skin Microenvironment, Animals
Source:Frontiers in Immunology
Publisher:Frontiers Media SA
Page Range:599
Date:March 2019
Official Publication:https://doi.org/10.3389/fimmu.2019.00599
PubMed:View item in PubMed

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